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US Patent 12065423 Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof

Patent 12065423 was granted and assigned to Celgene on August, 2024 by the United States Patent and Trademark Office.

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 US Patent 12065423 Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof

Article

Patent abstract

Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate. Pharmaceutical compositions comprising the crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate are also disclosed.

Infobox
Is a
Patent
Patent
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Patent Applicant
Celgene
Celgene
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Current Assignee
Celgene
Celgene
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120654230
Patent Inventor Names
Jerry Lee Atwood0
Date of Patent
August 20, 2024
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Patent Application Number
171496350
Date Filed
January 14, 2021
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Patent Citations
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US Patent 7119106 Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
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US Patent 7189740 Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
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US Patent 7393862 Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
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US Patent 7393863 Methods of using N-{[2-(2,6-dioxo(3-piperidyl)-1,3-dioxoisoindolin-4-yl]methyl}cyclopropyl-carboxamide for the treatment and management of myelodysplastic syndromes
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US Patent 7465800 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
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US Patent 7629360 Methods for the treatment of cachexia and graft v. host disease
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US Patent 7709031 Angiogenic agents from plant extracts, gallic acid, and derivatives
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US Patent 7709502 Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines
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US Patent 7855217 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
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US Patent 7863297 Methods of using 4-(amino)-2-(2,6-dioxo(3-piperidly))-isoindoline-3-dione for the treatment of myelodysplastic syndromes
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US Patent 7959566 Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated
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US Patent 7968569 Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
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US Patent 7994327 Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
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US Patent 8158653 Pharmaceutical compositions of 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-amino isoindoline
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US Patent 8188118 Method for treating multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione in combination with antibodies
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US Patent 8198262 Methods for treating multiple myeloma using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione
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US Patent 8198306 Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione in combination with a proteasome inhibitor
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US Patent 8204763 Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug
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US Patent 8207200 Methods for treating multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydroindol-2-yl)-piperidine-2,6-dione follow by autologous stem cell transplantation
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US Patent 8315886 Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated
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US Patent 8530498 Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
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US Patent 8589188 Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug
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US Patent 8626531 Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated
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US Patent 8648095 Methods for treating multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione in combination with proteasome inhibitor
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US Patent 8673939 Methods for treating multiple myeloma with 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione
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US Patent 8722647 Methods for treating amyloidosis using 4-(amino)-2-(2,6-Dioxo(3-piperidyl))- isoindoline-1,3-dione
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US Patent 8735428 Methods for treating multiple myeloma with 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione
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US Patent 8759375 Methods for treating multiple myeloma using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione in combination with proteasome inhibitor
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US Patent 8828427 Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
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US Patent 9101621 Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
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US Patent 9101622 Methods for treating newly diagnosed multiple myeloma 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione in combination with dexamethasone
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US Patent 9695146 Solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and a coformer, compositions and methods of use thereof
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US Patent 10093649 Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
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US Patent 10590103 Crystalline 4-amino-2-(2,6-dioxopiperidine-3-YL)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
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US Patent 6878733 Formulations for pharmaceutical agents ionizable as free acids or free bases
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US Patent 6896399 Coating material feeding apparatus and valve unit
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US Patent 6908432 Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug
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US Patent 7041680 (R) and (S) isomers of substituted 2-(2,6-dioxopiperidin-3-yl) phthalimides and 1-oxoisoindolines and methods of using the same
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Patent Primary Examiner
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Nizal S Chandrakumar
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CPC Code
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C07D 401/04
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