A method for applying cold atmospheric plasma treatment on target tissue. The method comprises the steps of selecting through a graphical user interface on a display a particular cancer cell line associated with the target tissue, retrieving in response to the selecting, with a computing device connected to the display, settings data from a database of cell line data and associated settings data in a storage, applying, with the computing device, the retrieved settings data to a cold atmospheric plasma system, and treating cancer tissue with cold atmospheric plasma at the retrieved settings. The method may further comprise displaying the retrieved settings on a display.