Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ning Li0
Hanne Bak0
William Markis0
John Mattila0
Xiaolin Tang0
Daniel B. Dix0
Chen Li0
Date of Patent
August 27, 2024
0Patent Application Number
163773710
Date Filed
April 8, 2019
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
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