A quick-release take-down assembly for a weapon, including a quick-release, spring-loaded cam lever or handle, or a set of clips, that enables a handler to quickly and efficiently release the upper assembly from the lower assembly to access the bolt, carrier, and other components of the weapon for cleaning and other purposes. The quick-release system eliminates the need for standard, sliding take-down pins that can become stuck, require detent pins/springs in order to stay in place, require tools, and/or become misaligned.