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US Patent 12076412 Antibody-drug conjugates through specific linker oligopeptides

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Philipp Probst0

Dragan Grabulovski0

Philipp Spycher0

Romain Bertrand0

Ramona Stark0

Isabella Attinger-Toller0

Date of Patent

September 3, 2024

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Patent Application Number

181889910

Date Filed

March 23, 2023

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Patent Citations

US Patent 9676721 Compounds and compositions for the inhibition of NAMPT

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US Patent 9717803 Enzymatic conjugation of polypeptides

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US Patent 9764038 Enzymatic conjugation of antibodies

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US Patent 10132799 Screening of conjugated antibodies

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US Patent 10434180 Enzymatic conjugation of polypeptides

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US Patent 10675359 Enzymatic conjugation of antibodies

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US Patent 10639291 Homogenous antibody drug conjugates via enzymatic methods

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US Patent 11396649 Site-specific conjugation to antibody lysine residues with solid-phase immobilized microbial transglutaminase MTG and MTG in solution

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Patent Primary Examiner

Elly-Gerald Stoica

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CPC Code

0

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Patent abstract

The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker comprising the structure (shown in N→C direction) (Sp

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