Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Edward Painter0
Ravi Upasani0
Jim Palmer0
Thomas Butler0
Matthew Welsch0
Brendan Kelly0
Sridhar Vempati0
Date of Patent
September 3, 2024
0Patent Application Number
180949290
Date Filed
January 9, 2023
0Patent Citations
Patent Primary Examiner
CPC Code
Patent abstract
Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.
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