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US Patent 12077755 Bioactive conjugates for oligonucleotide delivery

Patent 12077755 was granted and assigned to University of Massachusetts on September, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

University of Massachusetts

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Current Assignee

University of Massachusetts

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Anton Turanov0

Anastasia Khvorova0

Mehran Nikan0

Andrew Coles0

Neil Aronin0

Matthew Hassler0

Reka Haraszti0

Maire Osborn0

Date of Patent

September 3, 2024

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Patent Application Number

168127140

Date Filed

March 9, 2020

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Patent Citations

US Patent 7750144 Methods and compositions for enhancing the efficacy and specificity of RNA silencing

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US Patent 7772203 Methods and compositions for controlling efficacy of RNA silencing

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US Patent 7790867 Vaccinia virus-related nucleic acids and microRNA

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US Patent 7834171 Modified polynucleotides for reducing off-target effects in RNA interference

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US Patent 8013136 Oligonucleotides comprising a non-phosphate backbone linkage

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US Patent 8097752 Antiprotozoal ring-substituted phospholipids

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US Patent 8304530 Methods and compositions for enhancing the efficacy and specificity of RNA silencing

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US Patent 8309704 Methods and compositions for enhancing the efficacy and specificity of RNAi

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Patent Primary Examiner

Richard A Schnizer

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CPC Code

0

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Patent abstract

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.

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