Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Brian Callahan0
Timothy Owen0
Date of Patent
September 3, 2024
0Patent Application Number
169898430
Date Filed
August 10, 2020
0Patent Citations
...
Patent Primary Examiner
Patent abstract
A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.