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US Patent 12084651 Surface display of whole antibodies in eukaryotes

Patent 12084651 was granted and assigned to Merck Sharp & Dohme Limited on September, 2024 by the United States Patent and Trademark Office.

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Patent abstract

Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.

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