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US Patent 12089575 Genetically modified mouse that expresses humanized PD1 and PD-L1 proteins

Patent 12089575 was granted and assigned to Regeneron Pharmaceuticals on September, 2024 by the United States Patent and Trademark Office.

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Patent abstract

Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).

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