A bite block with inclined surfaces fits between a patient's upper and lower jaws to hold them apart and fixes the bite block position relative to the jaws. A support plate slides relative to the bite block to position a needle guide on the support plate along an axis of the support plate. A position stop on the support plate contacts the anterior border of the Ramus of the patient's mandible to position the needle guide along the axis. A syringe needle is guided by the needle guide to a predetermined location to administer anesthetic, preferably to the inferior alveolar nerve as it enters the mandible. The needle guide is inclined to avoid gaging and a tongue depressor attached to the support plate positions the patient's tongue.