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US Patent 12091710 Systems and methods for handling microfluidic droplets

Patent 12091710 was granted and assigned to Bio-Rad Laboratories on September, 2024 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent
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Patent attributes

Patent Applicant
Bio-Rad Laboratories
Bio-Rad Laboratories
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Current Assignee
Bio-Rad Laboratories
Bio-Rad Laboratories
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120917100
Patent Inventor Names
Darren Roy Link0
Date of Patent
September 17, 2024
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Patent Application Number
171745190
Date Filed
February 12, 2021
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Patent Citations
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US Patent 6918404 Irrigation and drainage based on hydrodynamic unsaturated fluid flow
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US Patent 6926313 High pressure capillary connector
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US Patent 6935768 Method and statistical micromixer for mixing at least two liquids
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US Patent 6936417 Gene expression in bladder tumors
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US Patent 6942978 Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
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US Patent 6949342 Prostate cancer diagnosis and outcome prediction by expression analysis
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US Patent 6960437 Nucleic acid amplification utilizing microfluidic devices
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...
Patent Primary Examiner
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Jennifer Wecker
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CPC Code
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B01L 2300/0864
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B01L 2300/0867
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B01L 2300/165
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B01L 2400/0415
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B01L 2400/0424
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B01L 2400/0487
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B01L 2400/086
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B01L 3/502715
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Patent abstract

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.

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