Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vladimir Presnyak0
Barry Ticho0
Stephen Hoge0
Nadege Briancon-Eris0
Kerry Benenato0
Athanasios Dousis0
Seymour de Picciotto0
Zhinan Xia0
...
Date of Patent
October 1, 2024
0Patent Application Number
169440140
Date Filed
July 30, 2020
0Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
The invention relates to mRNA therapy for the treatment of fibrosis and/or cardiovascular disease. mRNAs for use in the invention, when administered in vivo, encode human relaxin, isoforms thereof, functional fragments thereof, and fusion proteins comprising relaxin. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of relaxin expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient relaxin activity in subjects.
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