Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ao Ji0
Wenxu He0
Chuchu Sun0
Date of Patent
October 8, 2024
0Patent Application Number
174105740
Date Filed
August 24, 2021
0Patent Citations
0
...
Patent Primary Examiner
Patent abstract
The present disclosure relates to an applicable bio-conjugation process for preparing antibody-drug conjugates (ADCs) with improved homogeneity. As compared with conventional conjugation process, the homogeneity of antibody-drug conjugate (ADC) products generated from the bio-conjugation process can be dramatically improved. Specifically, in the ADCs prepared by the process of the present disclosure, the content of D0+D8 is less than 10 wt % and the content of D6 is less than 10 wt %. Moreover, the content of D4 is generally more than 65 wt %, for example, more than 70 wt %, and more than 77 wt %, while the content of D4 is normally less than 40 wt % in the ADCs prepared by conventional conjugation processes.
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