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US Patent 12110339 ICOS ligand variant immunomodulatory proteins and uses thereof

Patent 12110339 was granted and assigned to ALPINE IMMUNE SCIENCES, INC. on October, 2024 by the United States Patent and Trademark Office.

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Patent abstract

Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.

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