Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Chad A. Cowan0
Torsten B. Meissner0
Leonardo M. R. Ferreira0
Jack L. Strominger0
Date of Patent
October 8, 2024
0Patent Application Number
179936670
Date Filed
November 23, 2022
0Patent Citations
0
0
...
Patent Primary Examiner
CPC Code
Patent abstract
Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
