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US Patent 12110521 Engineered methionine gamma lyase variants

Patent 12110521 was granted and assigned to SYNTIS BIO, INC. on October, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

SYNTIS BIO, INC.

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Current Assignee

SYNTIS BIO, INC.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Stephanie Sue Galanie0

Vesna Mitchell0

Nikki D. Kruse0

Gjalt W. Huisman0

Kerryn McCluskie0

Leann Quertinmont Teadt0

Kristen Jean Vallieu0

Kierra Aleece Franklin0

Date of Patent

October 8, 2024

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Patent Application Number

177490340

Date Filed

May 19, 2022

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Patent Citations

US Patent 7058515 Methods for making character strings, polynucleotides and polypeptides having desired characteristics

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US Patent 7105297 Methods and compositions for cellular and metabolic engineering

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US Patent 7148054 Evolution of whole cells and organisms by recursive sequence recombination

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US Patent 7220566 Subtilisin variants

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US Patent 7288375 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

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US Patent 7384387 High throughput mass spectrometry

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US Patent 7421347 Identifying oligonucleotides for in vitro recombination

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US Patent 7430477 Methods of populating data structures for use in evolutionary simulations

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Patent Primary Examiner

Louise W Humphrey

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CPC Code

0

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Patent abstract

The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The present invention also relates to the use of the compositions comprising the engineered methionine gamma lyase polypeptides for therapeutic purposes.

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