Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Seah Lim0
Date of Patent
October 15, 2024
0Patent Application Number
183964660
Date Filed
December 26, 2023
0Patent Citations
Patent Primary Examiner
Patent abstract
This disclosure relates to dimeric immunotherapeutics that comprise two IgGs that are crosslinked with a disulfide bond. The two IgGs may be chimeras of two different heavy chains, in which one heavy chain includes a cysteine mutation that forms the disulfide bond, and the other heavy chain lacks the cysteine mutation. The presence of a cysteine mutation in only one of the heavy chains of an IgG avoids two disulfide bonds between the two IgGs, which increases the accessible orientations between the two crosslinked IgGs, and also avoids the formation of trimers and higher-order oligomers.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.