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US Patent 12121539 Chimeric antigen receptors and uses thereof

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Timothy John Sadlon0

Simon Charles Barry0

Justin Taylor Coombs0

Date of Patent

October 22, 2024

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Patent Application Number

157590460

Date Filed

September 10, 2016

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Patent Citations

US Patent 7531171 Antibodies to non-functional P2X

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US Patent 7888473 Non-functional P2X

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US Patent 8067550 Hybridomas producing antibodies against non functional P2X7 receptor

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US Patent 8080635 Non-functional P2X

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US Patent 8293491 Purinergic (P2X) receptors in extra-cellular body fluid

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US Patent 8399617 Non-functional P2X

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US Patent 8597643 Antibodies for binding to non-functional P2X

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US Patent 8658385 Purinergic (P2X) receptors in extra-cellular body fluid

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Patent Primary Examiner

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Patent abstract

The present invention relates to chimeric antigen receptors (CARs) directed to cells expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumours expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor and methods of treating and preventing cancer is a subject.

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