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US Patent 12123013 WPRE mutant constructs, compositions, and methods thereof

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Melinda Mata0

Mamta Kalra0

Steffen Walter0

Yannick Bulliard0

Ali Mohamed0

Date of Patent

October 22, 2024

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Patent Application Number

185012690

Date Filed

November 3, 2023

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Patent Primary Examiner

Jeremy C Flinders

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CPC Code

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Patent abstract

The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

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