Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Maia Vinogradova0
Jeanmarie Guenot0
Holger Wesche0
Luke Evnin0
Robert B. DuBridge0
Patrick Baeuerle0
Anand Panchal0
Date of Patent
October 29, 2024
0Patent Application Number
183570130
Date Filed
July 21, 2023
0Patent Citations
...
Patent Primary Examiner
Patent abstract
The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.
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