Devices, systems and methods for configuring structures and environs based on detected users and generic or known itineraries are described. A system may include: a hub having a data store, non-transiently storing computer instructions for a hub tracker engine (THE) and for a hub response engine (HRE) and a processor; a tracker node; and a responding device. The HTE instructs operations including fine or coarse user detection, and tracking operations. The system thereby tracks the user within a structure and determines whether to respond to the user. The HRE configures the responding device as at least one of a current responding device, a next responding device, and a destination responding device. Coarse user detection may include powering-on the tracker node, establishing a tracker link with the hub, communicating a tracker data signal to the hub, and analyzing the tracker data signal for a presence of the user at a location.