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US Patent 12134635 Interleukin 18 (IL-18) variants and fusion proteins comprising same

Patent 12134635 was granted and assigned to Sonnet Biotherapeutics, Inc. on November, 2024 by the United States Patent and Trademark Office.

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Patent abstract

Provided herein are variant human IL-18 (hIL-18) proteins and fusion proteins comprising the variant hIL-18 proteins. Such variant hIL-18 proteins exhibit biological IL-18 activity while having reduced or no detectable binding to inhibitory IL-18BP. Thus, in some embodiments, the variant hIL-18 proteins advantageously retain IL-18 biological activity in the presence of IL-18BP. Such variant hIL-18 and related fusion proteins find use, for example, in the treatment of cancer.

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