US Patent 6870033 Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies
Patent 6870033 was granted and assigned to Genentech on March, 2005 by the United States Patent and Trademark Office.
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Patent abstract
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.
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Patent Inventor Names
Gerarado A. Zapata0
Iphigenia Koumenis0
Leonard G. Presta0
Steven R. Leong0
Vanessa Hsei0
Zahra Shahrokh0
Date of Patent
March 22, 2005
0Patent Application Number
093550140
Date Filed
February 20, 1998
0Patent Primary Examiner
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US Patent 6870033 Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies
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