Patent 6887673 was granted and assigned to Bristol-Myers Squibb on May, 2005 by the United States Patent and Trademark Office.
A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.