Is a
Patent attributes
Patent Applicant
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Francoise Debart0
Jean Jacques Vasseur0
Phillip Dan Cook0
Yogesh Shantilal Sanghvi0
Date of Patent
May 31, 2005
0Patent Application Number
101533200
Date Filed
May 22, 2002
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
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