An airway clearance system and method produces high frequency chest wall oscillations (HFCWO) and increased airflow velocities through the air passages to clear the lungs of mucus. The system includes a chest wall force applicator to produce the HFCWO by applying an oscillating force component and a steady state (or bias line) force component. An air pressure input mouthpiece system that supplies airflow to a mouthpiece with a steady state, air component which tends to counteract or cancel the bias line force component.