A closure and container combination has in which anti-backoff capability the closure includes a top wall and a depending annular skirt having closure threading formed on an inner surface of the skirt. The closure threads mate with threads on the container. One or more anti-backoff members are formed on the inner surface of the skirt and/or the outer surface of the container neck and arranged and configured to frictionally engage the mating threading between the anti-backoff member and the threading to resist movement of the closure once secured onto the neck of the container.