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US Patent 6921667 Methods for direct detection of individual methotrexate metabolites

Patent 6921667 was granted and assigned to Prometheus Laboratories on July, 2005 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent Applicant
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Current Assignee
Prometheus Laboratories
Prometheus Laboratories
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
69216670
Patent Inventor Names
Russell B. Richerson0
Thierry Dervieux0
Date of Patent
July 26, 2005
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Patent Application Number
103840660
Date Filed
March 7, 2003
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Patent Primary Examiner
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Maureen M. Wallenhorst
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Patent abstract

The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a human undergoing methotrexate therapy; and detecting at least one resolved MTXPG, thereby determining a level of the resolved MTXPG. A method of the invention can be useful, for example, for determining a level of MTXPG3, MTXPG4 or MTXPG5 or for determining a level of each methotrexate polyglutamate species (MTXPG1 to MTXPG7) present in the cellular extract.

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