US Patent 6977244 Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
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Patent abstract
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. Used alone, or in conjunction with other antisense oligonucleotides, these compositions inhibit the proliferation of FL cancer cells.
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Patent Inventor Names
Ana M. Tari0
Gabriel Lopez-Berestein0
Mar Tormo0
Date of Patent
December 20, 2005
0Patent Application Number
087262110
Date Filed
October 4, 1996
0Patent Primary Examiner
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US Patent 6977244 Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
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