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US Patent 6979556 Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes

Patent 6979556 was granted and assigned to Genentech on December, 2005 by the United States Patent and Trademark Office.

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Laura Klimowski0

Daniel G. Yansura0

Dorothea Reilly0

Laura C. Simmons0

Date of Patent

December 27, 2005

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Patent Application Number

100207860

Date Filed

December 13, 2001

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Patent Citations Received

US Patent 11912773 Fc variants and methods for their production

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US Patent 12071476 IL-6 antibodies and fusion constructs and conjugates thereof

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US Patent 11866465 Oligomeric particle reagents and methods of use thereof

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US Patent 11913024 Methods for culturing cells and kits and apparatus for same

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US Patent 11912784 Methods of treating an eye disorder

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US Patent 12129477 Methods, kits, agents and apparatuses for transduction

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Patent Primary Examiner

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Patent abstract

The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.

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