Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Brian K. Kaspar0
Daniel A. Peterson0
Fred H. Gage0
Date of Patent
February 14, 2006
0Patent Application Number
100320470
Date Filed
December 21, 2001
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods are disclosed for transducing neurons with heterologous genes using retrograde viral transport. The methods disclosed employ substantially non-toxic vectors, such as adeno-associated virus vectors, that are capable of retrograde axonal transport to introduce and express genes in the neurons. This method has applications in the mapping of neural pathways, in stimulating or inhibiting the growth of neurons, and in the treatment of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
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