Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Philip E. Thorpe0
Rolf A. Brekken0
Date of Patent
June 6, 2006
0Patent Application Number
103735610
Date Filed
February 24, 2003
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate and prodrug compositions and methods using the new VEGF-specific antibodies are also provided.
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