Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jennifer T. Jones0
James A. Wells0
Marcus D. Ballinger0
Mark X. Sliwkowski0
Wayne J. Fairbrother0
Date of Patent
June 20, 2006
0Patent Application Number
100827470
Date Filed
February 22, 2002
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-β1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
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