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US Patent 7078383 ITI-D1 Kunitz domain mutants as HNE inhibitors

Patent 7078383 was granted and assigned to Dyax on July, 2006 by the United States Patent and Trademark Office.

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Patent abstract

Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are of particular interest: (a) Val15 or Ile15, (b) Ala16, (c) Phe18, (d) Pro19, (e) Arg1, (f) Pro2, and/or (g) Phe4.

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