Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael I. Sherman0
Bert Vogelstein0
Kenneth W. Kinzler0
Date of Patent
August 8, 2006
0Patent Application Number
098138240
Date Filed
March 22, 2001
0Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.
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