US Patent 7087719 Method for the crystallization of human serum albumin

Patent 7087719 was granted and assigned to GTC BIOTHERAPEUTICS, INC. on August, 2006 by the United States Patent and Trademark Office.

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Patent Inventor Names

Daniel E. Couto0

Kalevi Visuri0

Scott P. Fulton0

Sinikka Uotila0

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Patent abstract

The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reagents to maximize albumin crystallization. Solubility diagrams are utilized as the basis for process control of the invented method. The current invention specifically controls phosphate concentration, pH and temperature to precisely guide crystallization kinetics and crystal yield.

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=070877190

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