Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Thomas Mark Boyce0
Peter Malcolm Campbell0
Richard David Newcomb0
Robyn Joyce Russell0
Charles Claudianos0
Geoffrey Charles de Quetteville Robin0
Jeremy Colin Brownlie0
John Graham Oakeshott0
...
Date of Patent
August 15, 2006
0Patent Application Number
097769100
Date Filed
February 6, 2001
0Patent Primary Examiner
Patent abstract
The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc?E 7, in which the protein encoded by the DNA molecule differs from E 3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
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