A face mask for use in gas delivery applications, such as breathable gas or aerosol drug systems. The face mask includes a body having a peripheral edge for placement against the face of a wearer. The peripheral edge defines a single chamber over the nose and the mouth of the wearer. An inlet opening is formed on a surface of the body for supplying inhalation gas to the nose through the chamber. A vent assembly inwardly extends from the surface of the body to the chamber and seals around the mouth for passing exhalation gas to the exterior of the body.