A fastening assembly and method to releasably secure a panel of a novel screen room enclosure to a structure. The fastening assembly includes a clip having a channel portion fastened to a flat portion, the channel portion having an opening adapted to receive an edge of a panel, and, a locking fastener having an elongated locking member adjustable between a first position and a second position. The flat portion of the clip comprises a hole for accepting the locking fastener such that the locking member can pass through the hole when the locking member is in the first position, and cannot pass through the hole when the locking member is in the second position. A screen room enclosure to be used with an awning of a structure and releasably coupled to the structure with a fastening assembly. A method of securing a side panel of the screen room enclosure to the structure with the clip is disclosed.