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US Patent 7112337 Liposome composition for delivery of nucleic acid

Patent 7112337 was granted and assigned to ALZA on September, 2006 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Samuel Zalipsky0

Shi-Kun Huang0

Wei-Ming Zhang0

Date of Patent

September 26, 2006

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Patent Application Number

100206710

Date Filed

December 12, 2001

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Patent Citations Received

US Patent 12129223 Lipids for use in lipid nanoparticle formulations

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US Patent 11679158 Biodegradable lipids for the delivery of active agents

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US Patent 11712481 Lipid nanoparticle formulations

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US Patent 11976019 Cationic lipids for use in lipid nanoparticles

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US Patent 12065396 Lipids for use in lipid nanoparticle formulations

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Patent Primary Examiner

Gollamudi S. Kishore

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Patent abstract

A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.

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