The invention pertains to a thickened rinseless hand sanitizer composition comprising a quaternary ammonium compound. The invention also pertains to a method of applying to the skin of a human a thickened rinseless hand sanitizer composition that comprises a quaternary ammonium compound that evaporates off the skin. The invention further pertains to a thickened rinseless hand sanitizer composition comprising a quaternary ammonium compound with additional functional ingredients. Finally, the invention pertains to a thickened rinseless hand sanitizer composition comprising a quaternary ammonium compound composed of food additive ingredients.