Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
October 3, 2006
Patent Application Number
09528682
Date Filed
March 20, 2000
Patent Citations Received
Patent Primary Examiner
Patent abstract
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72, numbered relative to SEQ ID NO:1, of the A subunits mutated, preferably by substitution with Arg. The toxoid is useful as vaccine against an enterotoxigenic strain of E. coli and is produced by recombinant DNA means by site-directed mutagenesis. It is also an effective adjuvant.
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