US Patent 7122184 Specific monoclonal antibody against terbinafine
Patent 7122184 was granted and assigned to Novartis on October, 2006 by the United States Patent and Trademark Office.
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The invention concerns momoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immonogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.
US Patent 07122184 Specific monoclonal antibody against terbinafine US Patent 7122184 Specific monoclonal antibody against terbinafine
US Patent 07122184 Specific monoclonal antibody against terbinafine
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