US Patent 7122374 Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
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AβN3pE-42 is a β amyloid protein that accumulates specifically as a major constituent of senile plaque in the brains of both sporadic and familial Alzheimer's disease patients. The invention provides antibodies that specifically recognize AβN3pE-42 and can be expected to have a strong β amyloid-removing action. Particularly, humanized antibodies against AβN3pE-42 are useful to treat human neurodegenerative diseases. Further, since AβN3pE-42 is localized in the brain, the antibodies of the invention can avoid side effects such as kidney disorders caused by the formation of antigen-antibody complex in the blood. An agent for gene therapy using a vector in which a cDNA encoding a protein comprises the antigen-binding region of the antibody can be an efficient therapeutic drug for removing β amyloid from the brain.
US Patent 07122374 Amyloid beta-protein 3(pE)-42 antibodies and uses thereof US Patent 7122374 Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
US Patent 07122374 Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
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