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US Patent 7129261 Cytotoxic agents

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Valeri Martichonok0

Howard P. Ng0

Oliver L. Saunders0

Zhihong Li0

Danny P.C. McGee0

Geoffrey T. Yarranton0

Guoxian Wu0

Date of Patent

October 31, 2006

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Patent Application Number

101609720

Date Filed

May 31, 2002

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Patent Citations Received

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US Patent 11919956 Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3

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US Patent 11919962 Antibodies against IL-7R alpha subunit and uses thereof

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US Patent 11945880 Heterodimeric antibodies that bind CD3 and tumor antigens

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Patent Primary Examiner

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Patent abstract

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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