A cargo cover includes an inflatable portion and an interior panel spanning between the inflatable portion. The inflatable portion forms a periphery of the cover. An inflation port is located at one end of the cover and communicates with the inflatable portion. Prior to use, the cover may be rolled-up. The rolled-up cover is positioned over a cargo load, and an inflation source introduces air through the inflation port to inflate the inflatable portion. As the inflatable portion inflates, the cover unrolls and thereby self-deploys over the cargo load.