Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Keelung Hong0
Demetrois Papahadjopoulos0
Dmitri Kirpotin0
John W. Park0
Christopher C. Benz0
Date of Patent
November 14, 2006
0Patent Application Number
097975440
Date Filed
February 28, 2001
0Patent Primary Examiner
Patent abstract
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab' domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lipid, and a polyethylene glycol derivatized lipid. The invention also provides for growth-inhibiting immunoliposomes that lack growth-inhibiting therapeutic agents and yet are capable of inhibiting the growth and proliferation of target cells.
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