A driving device of a cartridge of a nail driver comprises a cartridge of a nail driver for receiving nails; a stop plate installed at one lateral side of the cartridge for resisting against the nails within the cartridge; the stop plate being formed by a first plane and a second plane; the stop plate being movably installed to the cartridge by using the second plane. The cartridge includes a first end surface and a second end surface; the first end surface having a nail groove; the second end surface being formed with at least one retaining hole and a receiving hole; a positioning unit; one end of the positioning unit installed to the positioning hole and another end thereof is installed to the receiving hole so as to adjust the position of the stop plate with respect to the second end surface.