A combination of a locking button and a spindle for a lock includes a spindle having a longitudinal hole and a locking button having a grip portion for manual turning and a shank that is mounted in the longitudinal hole of the spindle. A guiding groove is defined in a circumference delimiting the longitudinal hole and extending along a circumferential direction. The shank includes a coupling section including a protrusion engaged in the guiding groove and movable between two end walls delimiting the guiding groove, allowing the locking button to be movable between a locking position and an unlocking position.